Theoretical analysis of the cannabinoid action in breast cancer metabolic pathways by systems biology and sistematic literature review

Authors

  • Jonatan Telles Ramos Universidade de Caxias do Sul
  • Scheila de Avila e Silva Universidade de Caxias do Sul
  • Vanessa Ferreira Lemos Universidade Federal do Rio Grande do Sul https://orcid.org/0000-0003-1317-8791

DOI:

https://doi.org/10.54372/sb.2021.v16.3019

Keywords:

canabinoides, câncer de mama, canabidiol, gpcr, STAT3.

Abstract

Breast cancer is the most common and incident kind of tumor. Despite the significative advances on treatment, there are gaps regarding the understanding of the therapy resistance mechanisms. The cannabinoids have shown considerable activity in breast tumors treatment of both in vitro and in vivo. Given the heterogenic profile of this kind of tumor, and the complexity of the therapeutical potential of the cannabinoids, it is necessary to identify the acting metabolic pathways of these compounds for the development of medicines to treat diseases like breast cancer. In this paper, through a systematic literature review and data obtained at the StringDB database, it was aimed to explain the role of the cannabidiol cannabinoid on MDA-MB-231 breast cancer cells. It was found that the classic JAK-STAT pathway can be crucial for cannabidiol acting on breast cancer, knowing that the STAT3 protein can be activated through G-protein coupled receptors, which are a negative allosteric modulation target from cannabidiol. It was concluded that the cannabidiol’s effect on its respective receptor can promote their modulation and, as consequence, the non-activation of STAT3.

Author Biographies

Jonatan Telles Ramos, Universidade de Caxias do Sul

Área de Conhecimento de Ciências da Vida, Universidade de Caxias do Sul

Scheila de Avila e Silva, Universidade de Caxias do Sul

Área de Conhecimento de Ciências Exatas e Engenharias, Universidade de Caxias do Sul

Vanessa Ferreira Lemos, Universidade Federal do Rio Grande do Sul

Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande Sul

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Published

2021-10-13

How to Cite

Ramos, J. T. ., e Silva, S. de A. ., & Lemos, V. F. . (2021). Theoretical analysis of the cannabinoid action in breast cancer metabolic pathways by systems biology and sistematic literature review . SaBios- Journal of Health and Biology, 16(1), 1–14. https://doi.org/10.54372/sb.2021.v16.3019