COGUMELOS MEDICINAIS: UMA REVISÃO SOBRE COMPOSTOS BIOATIVOS E EFEITOS BIOLÓGICOS

Autores

  • Marcela Funaki dos Reis Faculdade Integrado de Campo Mourão

Palavras-chave:

efeito anti-diabético e redução do risco cardiovascular, efeito antimicrobiano, efeito anti-inflamatório, efeito antioxidante, antitumoral.

Resumo

Tradicionalmente cerca de 200 espécies de cogumelos são uma fonte alimentar e medicinal. Estas características conduziram diversas pesquisas com foco na composição química e efeitos biológicos promovidos. Assim, este estudo de revisão bibliográfica traz uma discussão acerca da composição em bioativos, bem como os efeitos biológicos promovidos e o seu potencial de utilização em terapias convencionais. É possível afirmar que os cogumelos são uma fonte de compostos bioativos, e por isso podem ser chamados de alimentos funcionais, e os produtos elaborados a partir de cogumelos podem ser chamados de nutracêuticos. Estes cogumelos promovem efeitos biológicos e o seu consumo pode beneficiar a saúde. Nesse sentido, são necessárias mais pesquisas clínicas que indiquem a dose de consumo adequada, bem como possíveis efeitos colaterais. 

MEDICINAL MUSHROOMS: REVIEW ON BIOACTIVE COMPOUNDS AND BIOLOGICAL EFFECTS

There are approximately 200 mushroom species constituting food and medicinal sources. Such characteristics triggered several research works focused on their chemical composition and biological effects. Current review discusses bioactive compounds, the biological effects, and their potential in conventional therapies. Since mushrooms are sources of bioactive compounds, they may be called functional food and the products prepared may be called nutraceutical compounds. Mushrooms trigger biological effects and their intake may be a great benefit to health. Further clinical research work is required that would indicate the adequate consumption dose and their possible side effects. 


Referências

(1) COHEN, N.; COHEN, J.; ASATIANI, M. D.; VARSHNEY, V. K.; YU, H. T.; YANG, Y. C.; LI, Y. H.; MAU, J. L.; WASSER, S. P. Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher basidiomycetes mushrooms. Int J Med Mushrooms, v. 16, n. 3, p. 273-291, 2014.

(2) LEE, K.H.; MORRIS-NATSCHEKE, S. L.; YANG, X.; HUANG, R.; ZHOU, T.; WU, S. F.; SHI, Q.; ITOKAWA, H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. v. 2, n. 2, p. 84-95, 2012.

(3) LINDEQUIST, U. The merit of medicinal mushrooms from a pharmaceutical point of view. Int J Med Mushrooms, v. 15, n. 6, p. 517-523, 2013.

(4) PERALTA, R. M.; OLIVEIRA, A. L.; ELER, G. J.; SOARES, A. A.; BRACHAT, A. Functional properties of edible and medicinal mushrooms. Curr Trends Microbiol, v. 4, p. 45-60, 2008.

(5) BARROS, L.; FALCÃO, S.; BAPTISTA, P. FREIRE, C.; VILAS-BOAS, M.; FERREIRA, I. C. F. R. Antioxidant activity of Agaricus sp. mushrooms by chemical, biochemical and electrochemical assays. Food Chem. v. 111, p. 61-66, 2008.

SOARES, A. A.; SÁ-NAKANISHI, A. B.; BRACHT, A.; GOMES DA COSTA, S. M.; KOEHNLEIN, E. A.; SOUZA, A. G. M.; PERALTA, R. M. Hepatoprotective Effects of Mushrooms. Molecules, v. 18, n. 7, p. 7609-7630, 2013.

(6) WONG, J.Y.; ABDULLA, M.A.; RAMAN, J. PHAN, C.W.; KUPPUSAMY, U.R. GOLBABAPOUR, S.; SABARATNAM, V. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. eCAM, v. 2013, 9 p., 2013. Acesso em: 08 de junho de 2014. Disponível em: < http://www.hindawi.com/journals/ecam/2013/492976/>.

(7) VINHAL, C. O.; VINHAL, C. R.; CARVALHO, G. N. M. R. Mushrooms of the genus Agaricus as functional foods. Nutr Hosp. v. 27, n. 4, p. 1017-1024, 2012.

(8) Chang S. T, Buswell J. A. Mushroom nutriceuticals. World J Microbiol Biotechnol. v. 12:473–6, 1996.

(9) ALVES, M. M.; FERREIRA, I. C. F. R.; DIAS, J.; TEIXEIRA, V.; MARTINS, A.; PINTADO, M. A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds. Planta Med. v.78, p. 1707–1718, 2012.

(10) MOHAMED, E. M.; FARGHALY, F. A. Bioactive Compounds of Fresh and Dried Pleurotus ostreatus Mushroom. IJBWI. v. 3, p. 4-14, 2014.

(11) KIMURA, T. Natural Products and Biological Activity of the Pharmacologically Active Cauliflower Mushroom Sparassis crispa. BioMed Res Inter. v. 2013, 9p. 2013. Acesso em: 08 de Julho de 2014. Disponível em: < http://www.hindawi.com/journals/bmri/2013/982317/ >.

(12) KALAČ, P. A review of chemical composition and nutritional value of wild-growing and cultivated mushrooms. J Sci Food Agric. v. 93, n. 2, p. 209-18, 2013.

(13) BARROS, L.; BAPTISTA, P.; FERREIRA, I. C. Effect of Lactarius piperatus fruiting body maturity stage on antioxidant activity measured by several biochemical assays. Food Chem Toxicol. v. 45, n. 9, p. 1731-1737, 2007.

(14) VOGEL, F. S.; McGARRY, S. J.; KEMPER, L. A.; GRAHAM, D. G. Bacteriocidal properties of a class of quinoid compounds related to sporulation in the mushroom, Agaricus bisporus. Am J Pathol. v. 76, n. 1, p. 165-174, 1974.

(15) YUAN, X. L.; YAN, L. H.; ZHANG, Q. W.; WANG, Z. M. Chemical constituents from fungus Armillaria mellea. J Chin Mater Med. v. 38, n. 16, p. 2671-2674, 2013.

(16) FERNANDES, N. A.; ISIKHUEMHEN, O. S.; OHIMAIN, E. I. Lignin degradation, ligninolytic enzymes activities and exopolysaccharide production by Grifola frondosa strains cultivated on oak sawdust. Braz J Microbiol. v. 42, n. 3, p. 1101-1108, 2011.

(17) PARK, Y. A.; LEE, K. T.; BAK, W. C.; KIM, M. K.; KA, K. H.; KOO, C. D. Eritadenin Contents Analysis in Various Strains of Lentinula edodes using LC-MS/MS. Korean J Mycol. v. 39, n. 3, p. 239-242, 2011.

(18) ZHANG, Y.; LIU, Z.; NG, TG.; CHEN, Z.; QIAO, W.; LIU, F. Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko. Biochimie. v. 99, p. 28-37, 2014.

(19) SOARES, A. A.; SÁ-NAKANISHI, A. B.; BRACHT, A.; GOMES-DA-COSTA, S. M.; KOEHNLEIN, E. A.; SOUZA, C. G. M.; PERALTA, R. M. Hepatoprotective Effects of Mushrooms, Molecules, v. 18, p. 7609-7630, 2013.

(20) KIMURA, T. Studies on pharmacological activities of the cauliflower mushroom Sparassis crispa. 2013. 90f. Dissertation (Master) - Kyoto University Research Information Repositor, 2013. Acesso em 08 de Julho de 2014. Disponível em: < http://hdl.handle.net/2433/180630 >.

(21) YI, C.; FU, M. CAO, X.; TONG, S.; ZHENG, Q.; FIREPONG, C. K.; JIAG, X.; XU, X.; YU, J. Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation. J Agric Food Chem. v. 61, n. 25, p. 5961-5971, 2013.

(22) KOBORI, M.; YOSHIDA, M.; OHNISHI-KAMEYAMA; SHINMOTO, H. Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells. Br J Pharmacol. v. 150, n. 2, p. 209–219, 2007.

(23) DA SILVA, A. F.; SARTORI, D.; MACEDO, F. C. Jr.; RIBEIRO, L. R.; FUNGARU, M. H.; MANTOVANI, M. S. Effects of β-glucan extracted from Agaricus blazei on the expression of ERCC5, CASP9, and CYP1A1 genes and metabolic profile in HepG2 cells. Hum Exp Toxicol. v. 32, n. 6, p. 647-54, 2013.

(24) PARK, H.; KA, K.H.; RYU, S.R. Enhancement of β-Glucan Content in the Cultivation of Cauliflower Mushroom (Sparassis latifolia) by Elicitation. Mycobiology. v. 42, n. 1, p. 41-45, 2014.

(25) VOLMAN, J. J.; MENSINK, R. P.; VAN GRIENSVEN, L. J.; PLAT, J. Effects of alpha-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects. Eur J Clin Nutr. v. 64, n. 7, p. 720-726, 2010.

(26) JESENAK, M.; HRUBISKO, M.; MAJTAN, J.; RENNEROVA, Z.; BANOVCIN, P. Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytother Res., v. 28, n.3, p. 471-474, 2014.

(27) LEI, H.; ZHANG, M.; WANG, Q.; GUO, S.; HAN, J.; SUN, H.; WU, W.; MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. v. 15, n. 4, p. 373-381, 2013.

(28) KANAGASABAPATHY, G.; MALEK, S. N. A.; MAHMOOD, A. A.; CHUA, K. H.; VIKINESWARY, S.; KUPPUSAMY, U. R. Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet. eCAM. v. 2013, 10p. 2013. Acesso em: 08 de Julho de 2014. Disponível em: < http://www.hindawi.com/journals/ecam/2013/185259/ >.

(29) ZHANG, B. Z.; INNGJIERDINGEN, K. T.; ZOU, Y. F.; RISE, F.; MICHAELSON, T. E.; YAN, P. S. PAULSEM, B.S Characterisation and immunomodulating activities of exo-polysaccharides from submerged cultivation of Hypsizigus marmoreus. Food Chem. v. 15, n. 163, p. 120-128, 2014.

(30) NASCIMENTO SANTOS, M.; MAGALHÃES, J. E.; CASTRO, L. S.; SOUSA PINHEIRO, T.; SABRY, D. A.; NOBRE, L. T.; LIMA, J. P.; BASEIA, I. G., LEITE, E. L. Effect of glucans from Caripia montagnei mushroom on TNBS-induced colitis. Int J Mol Sci. v. 15, n. 2, p.2368-2385, 2014.

(31) IKEWUCHI, J. C.; IKEWUCHI, C. C.; IFEANACHO, M. O.; IGBOH, N. M.; IJEH, I.I. Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing's: implications for the reduction of cardiovascular risk. J Ethnopharmacol. v. 150, n. 2, p. 466-476, 2013.

(32) CHENNUPATI, S.; VALLURU, S.; BHOGAVALLI, P. Studies On Antioxidant Capacity Of Petroleum Ether And Acetone Extracts Of Pleurotus Florida. AJBPR, v. 2, n. 2, p. 82-88, 2012.

(33) LI, H.; LEE, H. S.; MOON, B.; LEE, C. Antioxidant and anti-inflammatory activities of methanol extracts of Tremella fuciformis and its major phenolic acids. J Food Sci. v. 79, n. 4, p. C460-468, 2014.

(34) BARROS, L.; DUEÑAS, M.; FERREIRA, I. C.; SANTOS-BUELGA, C. Phenolic acids determination by HPLC-DAD-ESI/MS in sixteen different Portuguese wild mushrooms species. Food Chem Toxicol. v. 47, n. 6, p. 1076-1079, 2009.

(35) LEE, I. K.; KIM, Y. S.; JANG, Y. W.; JUNG, J. Y.; YUN, B. S. New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorg Med Chem Lett. v. 17, n. 24, p. 6678-6681, 2007.

(36) KETTAWAN, A.; CHANLAYA, K.; KONGKRACHICHAI, R.; CHAROENSIRI, R. Effects of Cooking on Antioxidant Activities and Polyphenol Content of Edible Mushrooms Commonly Consumed in Thailand. PJN. v.10, n. 11, p. 1094-1103, 2011.

(37) VANAMU, E.; NITA, S. Antioxidant capacity and the correlation with major phenolic compounds, anthocyanin, and tocopherol content in various extracts from the wild edible Boletus edulis mushroom. Biomed Res Int. v. 2013, 10p. 2013. Acesso em 03 de Julho de 2014. Disponível em: < http://www.hindawi.com/journals/bmri/2013/313905/>.

(38) PETROVIC, J.; STOJKOCIV, D.; REIS, F. S.; BARROS, L.; GLAMOCLIJA, J.; CIRIC, A.; FERREICA, I. C.; SOKOVIC, M. Study on chemical, bioactive and food preserving properties of Laetiporus sulphureus (Bull.: Fr.) Murr. Food Funct. v. 5, n. 7, p. 1441-51, 2014.

(39) TRIPATHI, A. M.; TIWARY, B. N. Biochemical constituents of a wild strain of Schizophyllum commune isolated from Achanakmar-Amarkantak Biosphere Reserve (ABR), India. World J Microbiol Biotechnol. v. 29, n. 8, p. 1431-1442, 2013.

(40) MONDAL, T.; SOME, R.; DUTTA, S. Studies on antioxidant and antimicrobial properties of some common mushrooms. JTBSRR. v. 2, n. 1, p. 60-67, 2013.

(41) YALTIRAK, T.; ASLIM, B.; OZTURK, S.; ALLI, H. Antimicrobial and antioxidant activities of Russula delica Fr. Food Chem Toxicol. v. 47, n. 8, p. 2052-2056, 2009.

(42) BARROS, L.; CALHELHA, R. C.; VAZ, J. A.; FERREIRA, I. C. R.; BAPTISTA, P.; ESTEVINHO, L. M. Antimicrobial activity and bioactive compounds of Portuguese wild edible mushrooms methanolic extracts. Eur Food Res Technol. v. 225, p. 151–156, 2007.

(43) PATEL, S.; GOYAL, A. Recent developments in mushrooms as anti-cancer therapeutics: a review. Biotech. v. 2, n. 1, p. 1-15, 2012.

(44) RONY, K. A.; AJITH, T. A.; MATHEW, J.; JANARDHAN, K. K. The medicinal cracked-cap polypore mushroom Phellinus rimosus (higher Basidiomycetes) attenuates alloxan-induced hyperglycemia and oxidative stress in rats. Int J Med Mushrooms. v. 15, n. 3, p. 287-300, 2013.

(45) JAYASURIYA, R.; WHITTAKER, M.; HALIM, G.; MATINEAU, T. Rural health workers and their work environment: the role of inter-personal factors on job satisfaction of nurses in rural Papua New Guinea. BMC Health Serv Res, v.2, n.156, p.12. 2012.

(46) LEI, H.; ZHANG, M.; WANG, Q.; GUO, S.; HAN, J.; SUN, H.; WU, W. MT- α -glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. v.15, n. 4, p. 373-81, 2013.

(47) KOYAYASHI, M.; KAWASHIMA, H.; TAKEMORI, K.; ITO, H.; MURAI, A.; MASUDA, S.; YAMADA, UEMURA, D.; HORIO, F. Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice. Biochem Biophys Res Commun. v. 427, n. 2, p. 299-304, 2012.

(48) CARVALHO, V. F.; COLTRO, P. S.; FERREIRA, M. C. Feridas em pacientes diabéticos, Rev Med. São Paulo. v. 89, n.3/4, p. 164-169. 2010.

(49) MENDONÇA, R. J.; COUTINHO-NETTO, J. Aspectos celulares da cicatrização. An Bras Dermatol. v. 84, n. 3, p. 257-62, 2009.

(50) CHENG, P. G.; PHAN, C. W.; SABARATNAM, V.; ABDULLAH, N; ABDULLA, M. A.; KUPPUSAMY, U. R. Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats. eCAM, v. 2013, 2013. Acesso em: 03 de Julho de 2014. Disponível em: < http://www.hindawi.com/journals/ecam/2013/671252/ >.

(51) SHAAN, B. D.; HARZHEIN, E.; GU, I. Perfil de risco cardíaco no diabetes mellitus e na glicemia de jejum alterada, Rev. Saúde Pública, v. 38, n. 4, p. 529-536, 2004.

(52) LU, X.; CHEN, H.; DONG, P.; FU, L.; ZHANG, X. Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. J Sci Food Agric. v. 90, n. 2, p. 276-80. 2010.

(53) OH, T. W.; KIM, Y. A.; JANG, W. J.; BYEON, J. I.; RYU, C. H.; KIM, J. O.; HA, Y. L. Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats. J Agric Food Chem. v.58, n. 7, p. 4113-9. 2014.

(54) AKYUZI, M.; ONGANER, A. N.; ERECEVIT, P.; KIRBAG, S. Antimicrobial Activity of some Edible Mushrooms in the Eastern and Southeast Anatolia Region of Turkey. GU J Sci, v. 23, n. 2, p. 125-130, 2010.

(55) SCLHILLACI, D.; ARIZZA, V.; GARGANO, M.L.; VENTURELLA, G. Antibacterial activity of mediterranean oyster mushrooms, species of genus pleurotus (higher basidiomycetes), Int J Med Mushrooms. v.15, n. 6, p. 591-594, 2013.

(56) MA, K.; BAO, L.; HAN, J.; JIN, T.; YANG, X.; ZHAO, F.; LI, S.; SONG, F.; LIU, M.; LIU, H. New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum. Food Chem. 2014, v. 15, p.143:239-245. 2013.

(57) ADEBAYO, E. A.; OLOKE, J. K.; AYANDELE, A. A.; ADEGUNLOLA, C. O. Phytochemical, antioxidant and antimicrobial assay of mushroom metabolite from Pleurotus pulmonarius – LAU 09 ( JF736658 ). J Microbiol Biotechnol , v. 2, n. 2, p. 366-374, 2012.

(58) SHANG, X.; LIU, R.; YU, K.; LI, P.; ZHAO, G.P. In Vitro Anti-Helicobacter pylori Effects of Medicinal Mushroom Extracts, with Special Emphasis on the Lion's Mane Mushroom, Hericium erinaceus (Higher Basidiomycetes). Int J Med Mushrooms, v.15, p. 165-174, 2013.

(59) RAMESH, C.H.; PATTAR, G. Antimicrobial properties, antioxidant activity and bioactive compounds from six wild edible mushrooms of western ghats of Karnataka, India. Pattar. Pharmacognosy Res, v.1, n.2, p. 107-102, 2010.

(60) KOSANIĆ, M; RANKOVIĆ, B.; DAŠIĆ M. Mushrooms as possible antioxidant and antimicrobial agents. Iran J Pharm Res. v. 11, p. 1095-102, 2012.

(61) MEERA, C. R.; CHANDRAN, S.; JAIN, R.; WILSON, W.; ANJANA, J. C.; RUVEENA, T. N. Antimicrobial and Anti-Oxidant Activities of Polysaccharides isolated from na Edible Mushroom, Pleurotus florida, Advanced Biotech., v.10, n.8, p. 9-11, 2011.

(62) SMÂNIA, E. F. A.; SMÂNIA, A. Jr.; LOUGUERCIO-LEITE, C. Cinnabarin synthesis by Pycnoporus sanguineus strains and antimicrobial activity against bactéria from food products. Rev. Microbiol. v. 29, n. 4, p. 317-320, 1998.

(63) CHAN, P.M.; KANAGASABAPATHY, G.; TAN, Y.S.; SABARATNAM, V.; KUPPUSAMY, UR. Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties. eCAM, v. 2013, 10 p., 2013. Acesso em: 08 de Julho de 2014. Disponível em: < http://www.hindawi.com/journals/ecam/2013/304713/>.

(64) DEBNATH, T.; PARK, S.R.; KIM, H.; JE, J.; LIM, B. O. Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts. Molecules. v. 18, n. 8, p. 9293-304, 2013.

(65) ZEMBRON-LACNY, A.; GAJEWSKI, A.; NACZK, M.; SIATKOWSKI, I. Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory reposnse to prolonged, J Physiol Pharmacol, v. 64, n. 2, p. 249-254, 2013.

(66) JEDINAK, A.; DUDHGAONKAR, S.; WU, Q.L., SIMON, J.; SLIVA, D. Anti-inflammatory activity of edible oyster mushroom is mediated through the inhibition of NF-κB and AP-1 signaling. Nutrit J, v.10, n. 52, 2011. Acesso em: 05 de Julho de 2014. Disponível em: < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120742/

(67) SANTOS, M. S. N.; MAGALHÃES, J. E. M.; CASTRO, L. S. E. P. W.; PINHEIRO, T. S.; SABRY, D. A.; NOBRE, L. T. D. B.; LIMA, J. P. M.; BASEIA, I. G.; LEITE, E. L. Effect of Glucans from Caripia montagnei Mushroom on TNBS-Induced Colitis. Int. J. Mol. Sci. v. 15, n. 2, p. 2368-2385, 2014.

(68) BIEDRON, R.; TANGEN, J. M.; MARESZ, H.; HETLAND, G. Agaricus blazei Murill - immunomodulatory properties and health benefits. FFHD. v. 2, n. 11, p. 428-447, 2012.

(69) YANG, Z.; XU, J.; FU, Q.; FU, X.; SHU, T.; BY, Y.; SONG, B. Antitumor activity of a polysaccharide from Pleurotus eryngii on mice bearing renal cancer. Carbohydr Polym. v. 95, n. 2, p. 615-20, 2013.

(70) CHANG, Y. H.; YAMG, J. L.; WU, C. L.; CHANG, S. J.; LU, K. W.; LIN, J. J.; HASIA, T. C., LIN, Y. T.; HO, C.C.; WOOD, W. G.; CHUNG, J. G. Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo. Biosci Biotechnol Biochem. v. 73, n. 12, p.2589-94, 2009.

(71) CHA, Y. J.; ALAM, N.; LEE, J. S.; LEE, K. R.; SHIM.M. J.; LEE, M. W.; KIM, H. Y.; CHEONG, J. C.; YOO, Y. B.; LEE, T. S. Anticancer and Immunopotentiating Activities of Crude Polysaccharides from Pleurotus nebrodensis on Mouse Sarcoma 180. Mycobiol. v. 40, n. 4, p. 236-43, 2012.

(72) TANIGAWA, K.; ITO, Y.; SAKAI, M.; KOBAYASHI, Y. Evaluation of quality of life and immune function in cancer patients receiving combined immunotherapy and oral administration of Lentinula edodes mycelia extract. Gan To Kagaku Ryoho. v.39, n. 12, p. 1779-1781, 2012.

(73) MASUDA, Y,; ITO, K.; KONISHI, M.; NANMA, H. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother, v. 59, n. 10, p. 1531-1541, p. 2010.

(74) LEE, H. H.; LEE, J. S.; CHO, J. Y.; KIM, Y. E.; HONG, E. K. Study on Immunostimulating Activity of Macrophage Treated with Purified Polysaccharides from Liquid Culture and Fruiting Body of Lentinus edodes. J Microbiol Biotechnol, v. 19, n. 6, p. 566–572, 2009.

(75) JI, Z.; TANG, Q.; ZHANG, J.; YANG, Y.; JIA, W.; PAN, Y. Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. J Ethnopharmacol. v. 112, p. 445-450, 2007.

(76) ISHII, O. L.; PRADOM C. K.; MAURO, M. O.; CARREIRA, C. M.; MANTOVANI, M. S.; RIBEIRO, L. R.; DICHI, J. B.; OLIVEIRA, R. J. Evaluation of Agaricus blazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities. Regul Toxicol Pharmacol. v. 59, n. 3, p. 412-422, 2011.

(77) PANDOLFI, F.; CIANCI, R.; PAGLIARI, D.; CASCIANO, F.; BAGALA, C.; ASTONE, A.; LANDOLFI, R.; BARONE, C. The Immune Response to Tumors asa Tool toward Immunotherapy. Clin Dev Immunol. v.2, n.2, p.107-112, 2011.

(78) YANG, B.K.; PARK, J.B.SONG, C.H. Hypolipidemic effect of an exobiopolymer produced from a submerged mycelial culture of Hericium erinaceus, Biosci, Biotechnol, Biochem. v. 67, p. 1292-1298, 2003.

(79) HALLIWELL, B. Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life, Plant Physiol. v. 141, p. 312-322, 2006.

(80) HASNIS, E.; REZNICK, A.Z. Antioxidants and health aging. IMAJ, v. 5, p. 368-370, 2003.

(81) DONKENA, K.V. YOUNG, C.Y.F.; TINDALL, D.J. Oxidative Stress and DNA Methylation in Prostate Cancer, Obstet. Gynecol. Int. , 2010. Disponível em: <http://downloads.hindawi.com/journals/ogi/2010/302051.pdf>. Acesso em: 20 de ago. de 2010.

(82) BOLLAN, B.J.; ULVIK, R. J. Release of iron from ferritin by xanthine oxidase, Biochem J. v. 234, p. 55-59, 1987.

(83) DRÖGE, W. Free Radicals in the Physiological Control of Cell Function, Physiological Reviews , v. 82, p. 48-80, 2002.

(84) VEGA, A.; CHACÓN, P.; ALBA, G.; BEKAY, R.E.L.; MONTESEITÍN, J.; MARTÍN-NETO, J.; SOBRINO, F. Modulation of IgE-dependent COX-2 gene expression by reactive oxygen species in human neutrophils, J Leukocyte Biol, v.80, p.152-163, 2006.

(85) BUFFENSTEIN, R.; EDREY, Y.H.; YANG, T. The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms. J Am Aging Assoc, v. 30, p. 99-109, 2008.

(86) LEE, J.S.; PARK, B.C.; KO, Y.J.; CHOI, M.K.; CHOI, H.G.; YONG, C.S.; LEE, J.S.; KIM, J.A. Grifola frondosa (Maitake Mushroom) water extract inhibits vascular endothelial Growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase phosphorylation, J Med Food, v. 11, p. 643-651, 2008.

(87) WU, J.; HECKER, J.G.; CHIAMVIMONVAT, N. Antioxidant enzyme gene transfer for ischemic diseases, Adv Drug Deliver Rev, v. 61, p. 351-36, 2009.

(88) FUKUI, H.; MORAES, C.T. The mitochondrial impairment, oxidative stress and neurodegeneration connection, reality or just an attractive hypothesis? Trends Neurosci, v. 31, p. 251-256, 2008.

(89) SELVI, S.; DEVI, U.; SUJA, S.; MURUGAN, S.; CHINNASWAMY, P. Comparison of non-enzyme antioxidant status of fresh and dried form of Pleurotus florida and Calocybe indica. Pakistan J SCI , v. 6, p. 468-471, 2007.

(90) Fukui H., Moraes C. T. The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? Trends Neurosci. v. 31, p. 251–256, 2008.

(91) FROUFE, H.J.C; ABREU, R.M.V.; FERREIRA, I.C.F.R. A QCAR model for predicting antioxidant of wild mushrooms. SAR and QSAR in Environ Res, v. 20, p. 579-590, 2009.

(92) MAU, J.L.; CHAO, G.R.; WU, K.T. Antioxidant properties of methanolic extracts from several ear mushrooms, J Agricul Food Chem, v. 49, p. 5461-5467, 2001.

(93) JAYAKUMAR, T.; RAMESH, E.; GERALDINE, P. Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl4-induced liver injury in rats, Food Chem Toxicol, v. 44, 1989-1996, 2006.

(94) KIM, M.Y.; SEGUIM, P.; AHN, J.K.; KIM, J.; CHUN, S.C.; KIM, E.H.; SEO, S.H.; KANG, E.Y.; KIM, S.L.; PARK, Y.J.; RO, H.M.; CHUNG, I.M. Phenolic compound concentration and antioxidant activities of edible and medical mushroom from Korea, J Agricul Food Chem, v. 56, 7265-7270, 2008.

(95) HU, S.H.; LIANG, Z.C.; CHIA, Y.C.C.; LIEN, J.L.; CHEN, K.S.; LEE, M.L.; WANG, J.C. Antihyperlipidemic and antioxidant effects of extracts from Pleurotus citrinopileatus, J Agricul Food Chem, v. 54, p. 2103-2110, 2006.

(96) JOSE, N.; JANARDHANAN, K.K. Antioxidant and antitumor activity of Pleurotus florida, Sci Corresp, v. 79, p. 941-943, 2000.

(97) ASIATINI, M.D.; ELISASHVILI, V.I.; WASSER, S.P.; REZNICK, A.Z.; NEVO, E. Free-radical scavenging activity of submerged mycelium extracts from higher basidiomycetes mushroom. Biosci, Biotechnol, Biochem. v. 71, p. 3090-3092, 2007.

(98) FERRARI, G. P. Determinação de compostos fenólicos totais e atividade anti-oxidante de cogumelos Comestíveis. 2007. 33f. Dissertação. (Mestrado em Ciências da Saúde) - Universidade Estadual de Maringá, Maringá, 2007.

(99) SILVA, A.C.; OLIVEIRA, M. C.; DEL RÉ, P. V.; JORGE, N. Utilização de extrato de cogumelo como antioxidante natural em óleo vegetal, Ciênc Agrotec. v. 33, p. 1103-1108, 2009.

(100) SIEGEL, R.; NASHADHAM, D.; JEMAL, A. Cancer statistics. CA Cancer J Clin. v. 63, n. 1, p.11-30, 2013.

(101) HANAHAN, D.; WEINBERG, R. A. Hallmarks of cancer: the next generation. Cell. v. 144, n. 5, p. 646-74. 2011.

(102) XU, L.; HUANG, J. J. H.; CHEUNG, P. C. K. Extract of Pleurotus pulmonarius Suppresses Liver Cancer Development and Progression through Inhibition of VEGF-Induced PI3K/AKT Signaling Pathway Wenwen. Plos One. v.7, n. 3, p. e34406, 2012.

(103) RODRIGUES, S. B. Caracterização do efeito antimutagênico do cogumelo Lentinula edodes (Berk.) Pegler no sistema methG1 em Aspergillus (=Emericella) nidulans. 2002. 52f. Dissertação (Mestrado) – Programa de Pós-Graduação em Agronomia, Universidade Estadual de Maringá, Maringá, 2002.

(104) RODRIGUES, S. B.; JABOR, I. A. S.; MARQUES-SILVA, G. G.; ROCHA, C. L. M. S. C. Avaliação do potencial antimutagênico do Cogumelo do Sol (Agaricus blazei) no sistema methG1 em Aspergillus (=Emericella) nidulans. Acta Scientiarum, v. 25, p. 513-517, 2003.

(105) PATEL, S.; GOYAL, A. Recent developments in mushrooms as anti-cancer therapeutics: a review. Biotech. v. 2, n. 1, p. 1-15, 2012.

(106) VENKATAKRISHMAN, V.; SHENBHAGARAMAN R.; GUNASUNDARI, D.; DANDAPANI, R.; JAGADISH, L. K. Antioxidant and antiproliferative effect of Pleurotus ostreatus, J Phytol. v. 2, n. 1, p. 22–28, 2010.

(107) NOVAES, M. R. C. G.; VALADARES, F.; REIS, M. C; GONÇALEVES, D. R.; MENEZES, M. D. C. The effects of dietary supplementation with Agaricales mushrooms and other medicinal fungi on breast cancer: evidence-based medicine. Clinics, v. 66, n. 12, p. 2133–2139. 2012.

(108) LEE, M.L.; TAN, N.H.; FUNG, S.Y.; TAN, C.S.; NG, S.T. The Antiproliferative Activity of Sclerotia of Lignosus rhinoceros (Tiger Milk Mushroom). eCAM, v. 2012, 5p., 2012. Acesso em: 02 de ag. De 2014. Disponível em: < http://www.hindawi.com/journals/ecam/2012/697603/ >.

(109) ZAILA, C. F. S.; ZURAINA, M. Y. F.; NORFAZLINA, M. N.; MUM, L. L.; NURSHAHIRAH, N.; RAJAB, N. F. Antiproliferative Effect of Lignosus rhinocerotis , the Tiger Milk Mushroom on HCT 116 Human Colorectal Cancer Cells, TOPROCJ. v. 13, p. 65–70, 2013.

(110) SHI, X.; ZHAO, Y.; JIAO, Y.; SHI, T.; YANG, X. ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells. PloS One, v. 8, n. 5, e64266, 2013.

(111) SONG, F.; LIU, Y.; KONG, X.; CHANG, W.; SONG, G. Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom : Inonotus Obliquus, Asian Pacific J Cancer Prev. v.14, n. 3, p 1571–1578, 2013.

(112) YOO, H.; HAN, S.; KIM, J.; CHO, C.; PARK, S.; LEE, S. Anti-metastatic and Immunomodulating Activity of Water-Soluble Components from Five Mushroom Extracts, The Journal of Korean Oriental Medicine. v.30, n.3, p. 61–69, 2009.

(113) GHAZANFARI, T.; RABE, S.Z.T.; TABASI, N.; MAHMOUDI, M. Study of cytotoxic and pro-apoptotic effect of medicinal mushroom Pleurotus florida in cancer cell lines. Pharmacologyonline. v.3, p. 774–783, 2011.

(114) SOARES, R.; MEIRELES, M.; ROCHA, A.; PIRRACO, A.; OBIOL, D.; ALONSO, E.; BALOGH, G. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation. J Med Food, v.14, n.6, p.563–72. 2011.

(115) FANG, N., LI, Q., YU, S., ZHANG, J., HE, L., RONIS, M. J. J., BADGER, T. M. Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. eCAM, v. 12, n. 2, p. 125–132, 2006.

(116) CHA, Y. J.; ALAM, N.; LEE, J. S.; LEE, K. R.; SHIM, M. J.; LEE, M. W.; KIM, H. Y.; CHEONG, J. C.; YOO, Y. B.; LEE, T. S. Anticancer and Immunopotentiating Activities of Crude Polysaccharides from Pleurotus nebrodensis on Mouse Sarcoma 180. Mycobiol. v. 40, n. 4, p. 236-43, 2012.

(117) OLUFEMI, A. E.; TERRY, A. O. A; KOLA, Anti-leukemic and immunomodulatory effects of fungal metabolites of Pleurotus pulmonarius and Pleurotus ostreatus on benzene-induced leukemia in Wister rats. Korean J Hemat, v.47, n.1, 67–73, 2012. doi:10.5045/kjh.2012.47.1.67

Downloads

Publicado

2015-07-31

Como Citar

Reis, M. F. dos. (2015). COGUMELOS MEDICINAIS: UMA REVISÃO SOBRE COMPOSTOS BIOATIVOS E EFEITOS BIOLÓGICOS. SaBios-Revista De Saúde E Biologia, 10(1), 149–164. Recuperado de https://revista2.grupointegrado.br/revista/index.php/sabios/article/view/1798

Edição

Seção

Artigos de Revisões/Review Papers